首页> 外国专利> Method for synthesizing n - 5 - (aminosulfonil) - 4 - methyl - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil) phenyl acetamide, acid, N - 5 - (aminosulfonil) - 4metil - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil0 - phenyl acetamide metanossulfu00f4nico monohydrate crystals, and pharmaceutical composition containing acid, N - 5 - (aminosulfonil) - 4 - methyl - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil) phenyl acetamide metanossulfu00f4nico monohydrate crystalline

Method for synthesizing n - 5 - (aminosulfonil) - 4 - methyl - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil) phenyl acetamide, acid, N - 5 - (aminosulfonil) - 4metil - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil0 - phenyl acetamide metanossulfu00f4nico monohydrate crystals, and pharmaceutical composition containing acid, N - 5 - (aminosulfonil) - 4 - methyl - 1,3 - thiazole ring - 2 - YL - N - methyl - 2 - 4 - (2 - piridinil) phenyl acetamide metanossulfu00f4nico monohydrate crystalline

机译：合成方法n-[5--（氨基磺腈）-4-甲基-1,3-噻唑环-2-YL]-N-甲基-2-[4-（2-吡啶酮）苯基]乙酰胺，酸，N- [5-（氨基磺腈）-4残基-1,3-噻唑环-2-YL]-N-甲基-2-[4-（2-吡咯烷酮-苯基）乙酰胺亚甲基磺砜一水合物晶体，以及含有酸的药物组合物， N-[5-（氨基磺腈）-4-甲基-1,3-噻唑环-2-YL]-N-甲基-2-[4-（2-吡咯腈）苯基]乙酰胺偏亚磺砜 n一水合物结晶

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to the crystalline mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide in a definite particle size distribution and a specific surface area range, which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions, as well as to pharmaceutical compositions containing said N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having the afore-mentioned particle size distribution and specific surface area range.

机译：本发明涉及N- [5-（氨基磺酰基）-4-甲基-1,3-噻唑-2-基] -N-甲基-2- [4-（2-吡啶基）苯基]的结晶甲磺酸盐一水合物盐乙酰胺在确定的粒径分布和比表面积范围内，已证明从药物组合物以及含有所述N- [5-（氨基磺酰基）-4-甲基-具有上述粒径分布和比表面积范围的1，3-噻唑-2-基] -N-甲基-2- [4-（2-吡啶基）苯基]乙酰胺甲磺酸酯一水合物。

著录项

公开/公告号BR112014003245A2

专利类型
公开/公告日2017-03-01

原文格式PDF
申请/专利权人 AICURIS GMBH & CO. KG.;
展开▼

申请/专利号BR20141103245
发明设计人 BIRGIT KEIL;DR. ALEXANDER BIRKMANN;DR. ALFONS GRUNENBERG;DR. ANDREAS LENDER;DR. DIETER HAAG;DR. WILFRIED SCHWAB;DR.JOACHIM REHSE;KURT VÖGTLI;
展开▼

申请日2012-09-26
分类号C07D417/12;A61K31/4402;A61P31;A61P31/22;
国家 BR
入库时间 2022-08-21 13:40:40

相似文献

专利
外文文献
中文文献