首页> 外国专利> in vitro method for detecting predisposition or diagnosis and / or prognosis of abnormal extracellular matrix protein (ECMP) deposition, method for selecting a therapeutic compound for a patient and in vitro method for determining the likelihood of a patient affected with a viral infection responds to treatment with an antiviral agent and / or an interferon

in vitro method for detecting predisposition or diagnosis and / or prognosis of abnormal extracellular matrix protein (ECMP) deposition, method for selecting a therapeutic compound for a patient and in vitro method for determining the likelihood of a patient affected with a viral infection responds to treatment with an antiviral agent and / or an interferon

机译:用于检测异常细胞外基质蛋白(ECMP)沉积的易感性或诊断和/或预后的体外方法,为患者选择治疗性化合物的方法以及用于确定患者受到病毒感染影响的可能性的体外方法用抗病毒药和/或干扰素

摘要

The present invention discloses the identification of a fibrosis susceptibility gene locus, the IL22RA2 gene locus, which can be used for detecting predisposition to, diagnosis and prognosis of fibrosis as well as for the screening of therapeutically active drugs. The invention further provides a method for determining the likelihood of a patient affected with a viral infection to respond to a treatment with an antiviral agent and/or an interferon, which method comprises determining alteration in IL22RA2 gene locus or in IL22RA2 expression or IL22RA2 protein activity in a biological sample of the patient.
机译:本发明公开了纤维化易感性基因位点IL22RA2基因位点的鉴定,其可用于检测纤维化的易感性,诊断和预后以及用于筛选治疗活性药物。本发明进一步提供了一种确定病毒感染患者对抗病毒剂和/或干扰素的治疗反应的可能性的方法,该方法包括确定IL22RA2基因位点或IL22RA2表达或IL22RA2蛋白活性的改变。在患者的生物样本中。

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