首页> 外国专利> il-6 mediated dysfunction treatment method, rheumatoid arthritis treatment method, article of manufacture, method of inhibiting the progression of joint structural damage, pharmaceutical composition, juvenile idiopathic arthritis (jia) treatment method and treatment method giant cell arteritis (gca)

il-6 mediated dysfunction treatment method, rheumatoid arthritis treatment method, article of manufacture, method of inhibiting the progression of joint structural damage, pharmaceutical composition, juvenile idiopathic arthritis (jia) treatment method and treatment method giant cell arteritis (gca)

机译:il-6介导的功能障碍治疗方法,类风湿关节炎治疗方法,制品,抑制关节结构损伤进展的方法,药物组合物,幼年特发性关节炎(jia)治疗方法和治疗方法巨细胞性动脉炎(gca)

摘要

The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.
机译:本申请公开了用于治疗诸如类风湿性关节炎(RA),青少年特发性关节炎(JIA),系统性JIA(sJIA),多关节病程JIA(pcJIA),系统性硬化症或巨细胞动脉炎(IL-6)的IL-6介导的疾病的治疗方法。 GCA),以及与白介素6受体结合的皮下注射抗体(抗IL-6R抗体)。特别地,本发明涉及固定剂量的抗IL-6R抗体的鉴定,例如抗IL-6R抗体的鉴定。托珠单抗,对IL-6介导的疾病的患者皮下给药安全有效。另外,公开了可用于皮下施用抗IL-6R抗体的制剂和装置。

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