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monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration.
monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration.
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机译：抗rgm蛋白的单克隆抗体，用于治疗视网膜神经纤维层变性。
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摘要
monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration. The present application describes rgm α-binding proteins, particularly monoclonal antibodies, and in particular humanized cdr-grafted versions thereof, which have the ability to bind rgm to and prevent the binding of rgm proteins to the rgm receptor and other rgm binding proteins. a, and therefore neutralize the function of rgm a, for use in treating retinal nerve fiber layer (cfnr) degeneration, as well as methods of therapeutic or prophylactic treatment of a mammal against cfnr degeneration.
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