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black bear parathyroid hormone and methods of using the black bear parathyroid hormone.

机译:黑熊甲状旁腺激素和使用方法黑熊甲状旁腺激素。

摘要

black bear parathyroid hormone and methods of using the black bear parathyroid hormone. black bear parathyroid hormone (pth) and functional fragments thereof are provided. Similarly provided are the methods of using black bear pth and functional fragments for growing camp in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of bax protein to bcl-2 protein expression levels in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; increasing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in an individual; Similarly provided are antibodies directed against black bear parathyroid hormone (pth) and functional fragments thereof.
机译:黑熊甲状旁腺激素和使用方法黑熊甲状旁腺激素。提供了黑熊甲状旁腺激素(pth)及其功能性片段。类似地提供了使用黑熊pth和功能性片段在骨形成细胞中生长营地的方法。减少骨形成细胞的凋亡;降低骨形成细胞中bax蛋白与bcl-2蛋白表达水平的比率;增加骨形成细胞中一种或多种骨基质蛋白,转录激活剂或转录调节剂的表达水平;增加个体中的骨矿物质密度,增加骨量,减少骨丢失或减少骨折的发生率,或其任何组合;类似地提供了针对黑熊甲状旁腺激素(pth)的抗体及其功能片段。

著录项

  • 公开/公告号BR112012013725A2

    专利类型

  • 公开/公告日2017-01-10

    原文格式PDF

  • 申请/专利权人 MICHIGAN TECHNOLOGICAL UNIVERSITY;

    申请/专利号BR20121113725

  • 发明设计人 SETH W. DONAHUE;

    申请日2009-12-07

  • 分类号C07K14/635;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:54

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