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首页> 外国专利> solvate of a salt of a macrocyclic compound, polymorphic form, processes for preparing the polymorphic form and a pharmaceutical composition, pharmaceutical composition, salt of a macrocyclic compound, and methods for stimulating gastrointestinal motility, for treating a gastrointestinal disorder and for treating an individual and kit

solvate of a salt of a macrocyclic compound, polymorphic form, processes for preparing the polymorphic form and a pharmaceutical composition, pharmaceutical composition, salt of a macrocyclic compound, and methods for stimulating gastrointestinal motility, for treating a gastrointestinal disorder and for treating an individual and kit

机译：大环化合物盐的溶剂化物，多晶型物，多晶型物和药物组合物的制备方法，药物组合物，大环化合物的盐，以及刺激胃肠蠕动，治疗胃肠道疾病和治疗个体的方法和套件

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solvate of a salt of a macrocyclic compound, polymorphic form, processes for preparing the polymorphic form and a pharmaceutical composition, pharmaceutical composition, salt of a macrocyclic compound, and methods for stimulating gastrointestinal motility, for treating a gastrointestinal disorder and for treating an individual and kit. The present invention provides novel salts and solvates of macrocyclic compounds that bind to and / or are functional ghrelin receptor (growth hormone secretatogo) agonists. The invention also relates to polymorphs of these salts and solvates, pharmaceutical compositions containing these salts or solvates and methods of using the pharmaceutical compositions. Such pharmaceutical compositions are useful as therapies for a variety of disease indications, in particular for the treatment and prevention of gastrointestinal disorders including, but not limited to, postoperative ileus, gastroparesis, including diabetic and postoperative gastroparesis, opioid bowel disease, chronic intestinal pseudo-obstruction, short bowel syndrome, functional gastrointestinal disorders and other disease states, in critical care situations or as a result of treatment with pharmaceutical agents. In addition, the pharmaceutical compositions have application in the treatment and prevention of metabolic and / or endocrine disorders, bone disorders, inflammatory disorders, hyperproliferative disorder, disorders characterized by apoptosis and genetic disorders.
机译：大环化合物盐的溶剂化物，多晶型物，多晶型物和药物组合物的制备方法，药物组合物，大环化合物的盐，以及刺激胃肠蠕动，治疗胃肠道疾病和治疗个体的方法和套件。本发明提供了结合和/或为功能性生长素释放肽受体（生长激素促分泌素）激动剂的大环化合物的新型盐和溶剂化物。本发明还涉及这些盐和溶剂化物的多晶型物，含有这些盐或溶剂化物的药物组合物以及使用该药物组合物的方法。此类药物组合物可用作多种疾病适应症的疗法，尤其是用于治疗和预防胃肠道疾病，包括但不限于术后肠梗阻，胃轻瘫，包括糖尿病和术后胃轻瘫，阿片类药物肠病，慢性肠假性肠梗阻。重症监护情况下或由于药物治疗导致的梗阻，短肠综合征，功能性胃肠道疾病和其他疾病。另外，所述药物组合物可用于治疗和预防代谢和/或内分泌疾病，骨疾病，炎性疾病，过度增殖性疾病，以细胞凋亡为特征的疾病和遗传疾病。

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