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Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes

机译:通过添加alphagal表位提高了肿瘤相关抗原的免疫原性

摘要

The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
机译:本发明涉及引起肿瘤细胞选择性靶向和杀死的方法和组合物。本发明描述了基于纯化的TAA蛋白或TAA-衍生的合成肽的预防或治疗性癌症疫苗,所述TAA蛋白或TAA-衍生的合成肽通过化学,酶促或化学酶促方法改变以引入αGal表位或αGal糖模拟性表位,以允许通过增强抗原的调理作用天然的抗αGal抗体刺激TAA的捕获和呈递,从而诱导针对肿瘤表达的TAA的体液和细胞免疫应答。因此,刺激动物的免疫系统产生肿瘤特异性的细胞毒性细胞和抗体,它们会攻击并杀死动物体内存在的肿瘤细胞。

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