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MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease
MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease
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机译：MiRNA作为帕金森病的新型治疗靶标和诊断生物标志物
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摘要
The disclosure provides pharmaceutical compositions including an oligonucleotide that down-regulates the over-expression of at least one miRNA of SEQ ID NOs: 1-283. The oligonucleotide may be complementary to the nucleotide sequence of at least one of SEQ ID NOs: 1-283, or hybridizes under stringent conditions to a nucleotide sequence of at least one of SEQ ID NOs: 1-283. Further provided are methods of diagnosing Parkinson's Disease (PD) in a subject. The methods may include detecting the level of expression of at least one miRNA of SEQ ID NOs: 1-283 in a biological sample from the subject, and comparing the level of expression in the sample to the level of expression in a reference. Further provided are methods for treating, preventing, or reducing the risk of PD. Kits are also provided.
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机译：本公开提供了药物组合物，其包含下调SEQ ID NO：1-283的至少一种miRNA的过表达的寡核苷酸。寡核苷酸可以与SEQ ID NO：1-283中的至少一个的核苷酸序列互补，或在严格条件下与SEQ ID NO：1-283中的至少一个的核苷酸序列杂交。还提供了诊断受试者的帕金森氏病（PD）的方法。所述方法可包括检测来自受试者的生物样品中的至少一种SEQ ID NO：1-283的miRNA的表达水平，并将样品中的表达水平与参照中的表达水平进行比较。还提供了用于治疗，预防或降低PD风险的方法。还提供了套件。
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