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DNA sequencing methods and detectors and systems for carrying out the same

机译：DNA测序方法，检测器和进行该测序的系统

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摘要

In some embodiments, an analyte detection system is provided that includes a nanochannel, an electrode arrangement, and a plurality of nanoFET devices disposed in the nanochannel. A plurality of nucleic acid base detection components can be used that include a plurality of nanopores, a plurality of nanochannels, a plurality of hybridization probes, combinations thereof, and the like. According to other embodiments of the present teachings, different coded molecules are hybridized to a target DNA molecule and used to detect the presence of various sequences along the target molecule. A kit including mixtures of coded molecules is also provided. In some embodiments, devices including nanochannels, nanopores, and the like, are used for manipulating movement of DNA molecules, for example, in preparation for a DNA sequencing detection. Nanopore structures and methods of making the same are also provided as are methods of nucleic acid sequencing using the nanopore structures. Surface-modified nanopores are provided as are methods of making them. In some embodiments, surfaced-modified nanopores for slowing the translocation of single stranded DNA (ssDNA) through the nanopore are provided, as are nanopores configured to detect each of a plurality of different bases on an ssDNA strand.
机译：在一些实施例中，提供了一种分析物检测系统，其包括纳米通道，电极布置以及设置在纳米通道中的多个nanoFET器件。可以使用包括多个纳米孔，多个纳米通道，多个杂交探针，其组合等的多个核酸碱基检测组分。根据本教导的其他实施方案，将不同的编码分子与靶DNA分子杂交，并用于检测沿靶分子的各种序列的存在。还提供了包括编码分子混合物的试剂盒。在一些实施方案中，包括纳米通道，纳米孔等的装置用于操纵DNA分子的运动，例如，以准备DNA测序检测。还提供了纳米孔结构及其制备方法，以及使用纳米孔结构进行核酸测序的方法。提供了表面改性的纳米孔及其制备方法。在一些实施方案中，提供了用于减慢单链DNA（ssDNA）通过纳米孔的转运的表面修饰的纳米孔，以及被配置为检测ssDNA链上多个不同碱基的每个的纳米孔。

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