首页> 外国专利> Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method

Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method

机译:包括肝羧酸酯酶1的用于肝癌诊断的血浆生物标志物工具和肝癌筛查方法

摘要

The present invention relates to a plasma biomarker for diagnosing hepatocellular carcinoma (HCC), in particular to the discovery of a protein in plasma using 2-D fluorescence differential gel electrophoresis (2-D DIGE), immunoprecipitation and Nano-liquid chromatography mass spectrometry (Nano-LC-MS/MS) system that was unknown on the basis of conventional techniques. By demonstrating the presence of liver carboxylesterase 1 (hCE1) in human plasma and confirming that its secretion level is higher in patients with HCC than in healthy volunteers, this invention may be used as a screening method to diagnose HCC at an early stage.
机译:本发明涉及用于诊断肝细胞癌(HCC)的血浆生物标志物,尤其涉及使用2-D荧光差分凝胶电泳(2-D DIGE),免疫沉淀和纳米液相色谱质谱法在血浆中发现蛋白质的方法( Nano-LC-MS / MS)系统,这是传统技术所未知的。通过证明人血浆中肝羧酸酯酶1(hCE1)的存在并证实其分泌水平在HCC患者中比健康志愿者更高,本发明可以用作早期诊断HCC的筛选方法。

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