首页> 外国专利> Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus

Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus

机译:严重糜烂性口腔扁平苔藓患者疾病活动性与人乳头瘤病毒16特异性CD8 + T细胞克隆扩增的相关性

摘要

A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
机译:发现口腔中的扁平苔藓(OLP)的特征是活化的CD8 + T细胞大量克隆扩增,HPV 16特异性CD8 + T细胞频率增加),表明HPV感染与免疫不良过程之间存在因果关系。本发明涉及用于诊断和治疗OLP患者的组合物和方法。

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