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Nano-targeted delivery of protease, polymerase inhibitors with or without immune modulators in the treatment of hepatitis C

机译：纳米靶向递送蛋白酶，聚合酶抑制剂（带有或不带有免疫调节剂）在丙型肝炎的治疗中

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摘要

This disclosure concerns novel formulation and Nanoformulations as defined in the specification and compositions comprising combination of HCV protease and polymerase inhibitors, with or without interferon, along with anti-fibrotic/anti-hemolytic agents' combination of naturally driven Polyphenol/Thiols, and Non-anticoagulant GAGs. These compounds are effective antiviral agents, especially in inhibiting the function of the various genotypes of Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising nano-targeted delivery of novel nanoformulation containing combined composition for HCV and/or hepatic targeted delivery for improved efficacy and safety.

机译：本公开内容涉及说明书中定义的新颖制剂和纳米制剂，以及包含HCV蛋白酶和聚合酶抑制剂的组合，具有或不具有干扰素，以及天然驱动的多酚/硫醇的抗纤维化/抗溶血剂的组合，以及非抗凝GAG。这些化合物是有效的抗病毒剂，特别是在抑制丙型肝炎病毒（HCV）的各种基因型的功能中。因此，本公开还涉及通过使用这些新颖的化合物或包含用于HCV和/或肝靶向递送的组合的组合物的新颖纳米制剂的纳米靶向递送的治疗HCV相关疾病或病症的方法，以改善功效和安全性。

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公开/公告号US9597351B2

专利类型
公开/公告日2017-03-21

原文格式PDF
申请/专利权人 SHAKER A. MOUSA;
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申请/专利号US201514614496
发明设计人 SHAKER A. MOUSA;
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申请日2015-02-05
分类号A61K31/353;A61K31/7056;A61K31/7072;A61K31/198;A61K31/737;A61K45/06;A61K31/726;A61K31/728;A61K31/734;A61K31/7032;A61K9/00;A61K9/16;A61K9/20;
国家 US
入库时间 2022-08-21 13:44:15

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