首页> 外国专利> A METHOD OF IDENTIFYING A NEONATE AT RISK OF HAVING OR DEVELOPING HYPOXIC-ISCHAEMIC ENCEPHALOPATHY (HIE)

A METHOD OF IDENTIFYING A NEONATE AT RISK OF HAVING OR DEVELOPING HYPOXIC-ISCHAEMIC ENCEPHALOPATHY (HIE)

机译:识别有新生儿缺氧缺血性脑病(HIE)风险的新方法

摘要

A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE.
机译:一种用于筛选苦恼的新生儿患有HIE或发展为HIE的风险的方法,该方法包括以下步骤:分析从受苦的新生儿,其母亲或从脐带或胎盘获得的生物学样品中是否含有大量的miR-374a。将样品中的miR-374a的丰度与参考值miR-374a进行比较,其中与参考值的miR-374a丰度相比,样品中miR-374a的丰度降低表明正在苦恼的新生儿有患或发展HIE的风险。严重HIE的风险可以通过分析受苦的新生儿的生物学样品来确定,该生物学样品被鉴定为存在多种代谢产物(包括琥珀酸酯,甘油,丙酮和3-羟基丁酸酯)的HIE风险,并提供甘油和琥珀酸酯的总和丙酮和3-羟基丁酸酯的总和;并将总和与重度HIE的风险相关。

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