首页> 外国专利> ANIMAL MODELS OF AGE-RELATED DISORDERS AND AGE-SENSITIVE TRAITS ASSOCIATED WITH SENESCENCE-INDUCING STIMULI AND USES THEREOF

ANIMAL MODELS OF AGE-RELATED DISORDERS AND AGE-SENSITIVE TRAITS ASSOCIATED WITH SENESCENCE-INDUCING STIMULI AND USES THEREOF

机译:与年龄诱发障碍相关的年龄相关疾病和年龄敏感性状的动物模型及其用途

摘要

This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.
机译:本公开提供了针对年龄相关疾病和年龄敏感性状的非人类动物模型,特别是由衰老诱导性刺激引起的那些,其中所述模型包含由衰老细胞选择性表达的转基因。本公开进一步提供了使用动物模型鉴定有效治疗或预防与年龄有关的疾病和年龄敏感性状的治疗剂的方法,使用此类方法鉴定的治疗剂,包含鉴定的治疗剂的药物组合物以及治疗或预防年龄的方法相关的疾病和对年龄敏感的特征。

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