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Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
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机译:对肿瘤坏死因子相关的凋亡诱导配体受体具有选择性的抗体及其用途
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摘要
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
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