首页> 外国专利> Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

机译:对肿瘤坏死因子相关的凋亡诱导配体受体具有选择性的抗体及其用途

摘要

An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
机译:本发明的抗体与人DR5相互作用以在受体下游产生激动或拮抗作用,包括抑制细胞增殖和凋亡。已经阐明了抗DR5抗体的核酸序列和氨基酸序列,并且已经产生了包含和表达这些序列的载体和细胞。详细介绍了抗体的方法和用途,包括治疗细胞凋亡相关疾病和治疗细胞生长失调。

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