首页> 外国专利> Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis

Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis

机译：立体异构体肽，它们的聚合物结合物，它们在纳米颗粒中的包封及其在治疗由异常血管生成引起的疾病中的用途

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摘要

This invention discloses the creation of a novel single ligand-targeted multi-stereoisomer peptide-polymer conjugate compounds comprising a group of different synthetic and chemically modified stereoisomer peptides that have been conjugated to a biocompatible polymer carrying a peptide ligand for targeted delivery and/or encapsulated in ligand targeted polymer nanoparticles. The unique physicochemical properties of the stereoisomer peptides provide therapeutic compounds with ideal biopharmaceutical properties. The stereoisomer peptides carried by the polymer are delivered to cells or tissues to inhibit, suppress, block, antagonize or disrupt, simultaneously and independently, the functional domain of different disease causing proteins. Therefore the compounds are novel therapeutics for the treatment of abnormal angiogenesis and inflammation which are the hall mark of most human diseases including but not limited to all cancers, metastasis, eye retinopathies, cardiovascular, brain, and neurodegenerative disorders, diabetes, and diseases caused by infectious microorganisms including virus, bacteria, fungi, and parasites.

机译：本发明公开了新型的靶向单配体的多立体异构体肽-聚合物共轭化合物的制备，该化合物包括一组不同的合成和化学修饰的立体异构体肽，它们已经与带有肽配体的生物相容性聚合物缀合，用于靶向递送和/或封装。在配体靶向的聚合物纳米颗粒中。立体异构体肽的独特物理化学性质为治疗性化合物提供了理想的生物药物特性。聚合物携带的立体异构体肽被递送至细胞或组织，以同时，独立地抑制，抑制，阻断，拮抗或破坏不同致病蛋白质的功能域。因此，所述化合物是用于治疗异常血管生成和炎症的新颖疗法，所述异常血管生成和炎症是大多数人类疾病的标志，包括但不限于所有癌症，转移，眼视网膜病，心血管，脑和神经退行性疾病，糖尿病和由以下疾病引起的疾病：传染性微生物，包括病毒，细菌，真菌和寄生虫。

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公开/公告号US9790286B2

专利类型
公开/公告日2017-10-17

原文格式PDF
申请/专利权人 LUCIA IRENE GONZALEZ;
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申请/专利号US201414521600
发明设计人 LUCIA IRENE GONZALEZ;
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申请日2014-10-23
分类号C07K17/08;A61K47/48;C07K7/06;C07K7/08;C07K7/64;C08F222/38;C08G63/91;C12N9/96;A61K38;
国家 US
入库时间 2022-08-21 13:47:40

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