首页> 外国专利> COMPOSITION FOR PROMOTING CHONDROCYTE DIFFERENTIATION OR TREATING CARTILAGE DISEASES, CONTAINING KLF10 EXPRESSION INHIBITOR, AND METHOD FOR PROMOTING CARTILAGE DIFFERENTIATION BY USING SAME

COMPOSITION FOR PROMOTING CHONDROCYTE DIFFERENTIATION OR TREATING CARTILAGE DISEASES, CONTAINING KLF10 EXPRESSION INHIBITOR, AND METHOD FOR PROMOTING CARTILAGE DIFFERENTIATION BY USING SAME

机译：包含KLF10表达抑制剂的促进软骨细胞分化或治疗软骨疾病的组合物，以及通过使用相同的方法促进软骨分化的方法

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摘要

The present invention relates to a Krueppel-like factor 10 (KLF10) gene expression inhibitor promoting cartilage differentiation, and more specifically, to: a composition for promoting chondrocyte differentiation or treating cartilage diseases, containing a KLF10 gene expression inhibitor promoting cartilage differentiation and inhibiting the hypertrophy and dedifferentiation of chondrocytes; a cell therapeutic agent containing the composition; a method for promoting cartilage differentiation in bone marrow stem cells, comprising a step of expressing the composition in bone marrow stem cells; and a method for screening a chondrocyte differentiation promoter or a chondrocyte therapeutic agent. The present invention first examined the generation inhibition mechanism of indian hedgehog (IHH) protein of which the molecular biological mechanism has not yet been clearly examined, and ascertained that chondrocyte differentiation is promoted and chondrocyte hypertrophy is inhibited when chondrocyte differentiation is induced by expressing the KLF10 expression inhibitor in bone marrow stem cells. Therefore, the present invention has an advantage of enabling the use of bone marrow stem cells, which express a KLF10 expression inhibitor, as a chondrocyte therapeutic agent.

机译：本发明涉及促进软骨分化的Krueppel样因子10（KLF10）基因表达抑制剂，更具体地说，涉及：促进软骨细胞分化或治疗软骨疾病的组合物，其包含促进软骨分化并抑制软骨分化的KLF10基因表达抑制剂。软骨细胞肥大和去分化;包含所述组合物的细胞治疗剂;一种促进骨髓干细胞软骨分化的方法，其包括在骨髓干细胞中表达该组合物的步骤。以及筛选软骨细胞分化促进剂或软骨细胞治疗剂的方法。本发明首先检查了尚未明确检查其分子生物学机制的印度刺猬（IHH）蛋白的生成抑制机制，并确定了通过表达KLF10诱导软骨细胞分化时软骨细胞分化得到促进并且软骨细胞肥大被抑制。骨髓干细胞中的表达抑制剂。因此，本发明具有能够将表达KLF10表达抑制剂的骨髓干细胞用作软骨细胞治疗剂的优点。

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公开/公告号US2017016003A1

专利类型
公开/公告日2017-01-19

原文格式PDF
申请/专利权人 DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE (KHIDI);
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申请/专利号US201415108525
发明设计人 GUN-IL IM;JONG-MIN LEE;
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申请日2014-12-30
分类号C12N15/113;C12Q1/68;C12N5/077;
国家 US
入库时间 2022-08-21 13:49:20

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