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Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation

机译:关节镜冲洗液和外周血管收缩及抑制疼痛和炎症的方法

摘要

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that demonstrates substantial agonist activity at alpha adrenergic receptors and that is selected for peripheral (local) vasoconstriction and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and/or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents.
机译:一种在关节镜手术过程中围手术期抑制各种疼痛和炎症过程的方法和解决方案。该溶液优选包含在α肾上腺素能受体上表现出显着激动剂活性的血管收缩剂,并被选择用于在生理学载体例如盐水或乳酸林格氏溶液中稀释浓度的外周(局部)血管收缩和一种或多种其他疼痛和炎症抑制剂。 。该溶液是通过在外科手术过程中连续冲洗伤口而施加的,以用于外周血管收缩和抑制疼痛和/或炎症,同时避免了与全身性使用大剂量药剂有关的不良副作用。

著录项

  • 公开/公告号US2017246150A1

    专利类型

  • 公开/公告日2017-08-31

    原文格式PDF

  • 申请/专利权人 OMEROS CORPORATION;

    申请/专利号US201615392335

  • 申请日2016-12-28

  • 分类号A61K31/4174;A61K9/08;A61K31/407;A61K31/196;A61K31/405;A61K31/192;A61K31/135;

  • 国家 US

  • 入库时间 2022-08-21 13:49:48

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