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PROTEIN FUNCTIONAL AND SUB-CELLULAR ANNOTATION IN A PROTEOME

机译：蛋白质组中的蛋白质功能和亚细胞标记

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摘要

Techniques are disclosed for identifying the likely functionality and sub-cellular localization of individual proteins by first creating a protein-protein interaction network where protein pairs are created from data available from databases and experimental results, and by guessing potential interacting protein pairs where no data exists. Inside each protein pair, mutual likely functionality and localization annotations are made using the known functionalities and localization of the two proteins. The resulting annotated proteins are clustered according to similarity of their annotations and for each cluster iterative mutual annotations in each protein pair enrich the previous functional annotations until no more functionality annotations can be made and results in proteins with at least one assigned functionality and localization duet. Ranking of the resulting assignments is done using the specificity and confidence of the assignment.

机译：公开了用于识别单个蛋白质可能的功能和亚细胞定位的技术，方法是首先创建一个蛋白质-蛋白质相互作用网络，在该网络中根据数据库和实验结果中的可用数据创建蛋白质对，并通过猜测不存在数据的潜在相互作用蛋白质对。在每个蛋白质对内部，使用两种蛋白质的已知功能和位置进行相互可能的功能和定位注释。生成的带注释的蛋白质根据其注释的相似性进行聚类，并且对于每个聚类，每个蛋白质对中的迭代相互注释丰富了先前的功能注释，直到无法进行更多的功能注释，并产生具有至少一个指定的功能和定位二重性的蛋白质。使用作业的特异性和可信度对结果作业进行排名。

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公开/公告号US2017076036A1

专利类型
公开/公告日2017-03-16

原文格式PDF
申请/专利权人 KONSTANTINOS THEOFILATOS;CHRISTOS DIMITRAKOPOULOS;SEFERINA MAVROUDI;AIGLI KORFIATI;CHRISTOS ALEXAKOS;
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申请/专利号US201615361461
发明设计人 CHRISTOS DIMITRAKOPOULOS;SEFERINA MAVROUDI;KONSTANTINOS THEOFILATOS;CHRISTOS ALEXAKOS;AIGLI KORFIATI;
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申请日2016-11-27
分类号G06F19/18;G06N99/00;G06N7/00;
国家 US
入库时间 2022-08-21 13:50:11

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