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Human Sperm Fibrous Sheath (FS) Proteins: New Target Antigens For Use In Therapeutic Cancer Vaccines And Diagnostic Screening And Methods Of Using Same
Human Sperm Fibrous Sheath (FS) Proteins: New Target Antigens For Use In Therapeutic Cancer Vaccines And Diagnostic Screening And Methods Of Using Same
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机译：人精子纤维鞘（FS）蛋白：用于治疗癌症疫苗和诊断筛选的新靶标抗原及其使用方法
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摘要
Cancer vaccines were demonstrated to be promising strategies for cancer treatment; however these strategies are limited by the paucity of target antigens that provoke an effective immune response. The Inventors of the present patent application propose that sperm fibrous sheet proteins constitute a new class of potential antigens for use in the development of effective, durable cancer vaccines. This hypothesis is supported by the expression of the sperm fibrous sheath protein, known as Sperm protein 17 (Sp17), which is detected in tumors of unrelated histological origin. It has the ability to induce T-cell based immune responses. The expression of the Sperm protein 17 (Sp17) in tumors of unrelated histological origin, and its' natural localization in the human sperm fibrous sheath (FS), led the Inventors to hypothesize that FS proteins might represent a new potential class of target antigens useful for developing cancer vaccines, as well as diagnostic and therapeutic treatments.
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