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PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES

机译：结核分枝杆菌表达而不是卡介苗表达的蛋白及其作为诊断试剂和疫苗的用途

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摘要

The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

机译：本发明涉及用于在结核分枝杆菌中产生免疫应答并诊断感染的疾病的试剂。结核。

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公开/公告号US2017043038A1

专利类型
公开/公告日2017-02-16

原文格式PDF
申请/专利权人 RUTGERS THE STATE UNIVERSITY OF NEW JERSEY;
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申请/专利号US201615335920
发明设计人 MARIA LAURA GENNARO;
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申请日2016-10-27
分类号A61K49;
国家 US
入库时间 2022-08-21 13:51:37

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6. Immune profiling of leprosy and tuberculosis patients to 15-mer peptides of Mycobacterium leprae and M. tuberculosis GroES in a BCG vaccinated area: implications for development of vaccine and diagnostic reagents [O] . Rabia Hussain, Firdaus Shahid, Shahid Zafar, 2004

7. Recombinant bacillus Calmette-Guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model [O] . M. A. Horwitz, G. Harth, B. J. Dillon, 2000

1. Construction, Expression and Identification of a Recombinant BCG Vaccine Encoding Human Mycobacterium Tuberculosis Heat Shock Protein 65 [J] . 戴五星 ,梁靓 ,高红 . 华中科技大学学报（医学）（英德文版） . 2004,第002期

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