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IPS cell-derived myocardial model cells having normal inward potassium current characteristics
IPS cell-derived myocardial model cells having normal inward potassium current characteristics
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机译:具有正常内向钾电流特征的IPS细胞衍生的心肌模型细胞
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摘要
An object of the present invention is to provide an evaluated cell and its establishment method and a screening method of a test substance using the same, to be used for an evaluation system for detecting QT interval prolonging action and proarrhythmic property in drug research and development . It is derived from an induced pluripotent stem cell (iPS cell) and expresses at least one intracellular gene of cardiac troponin T (TnT), connexin 43 (Cx 43), or -actinin (-actinin) Characterized in that the Kir2.1 channel is expressed by the introduced KCNJ2 gene, the maximum diastolic potential when electrical stimulation is given is-85 to-65 mV, and does not have spontaneous periodic contractile activity Cells are prepared.
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