首页> 外国专利> Method for preparing androgen receptor-dependent breast cancer cell line, screening method using the cell line, and determination method, kit and marker for obtaining dependence on androgen receptor activity in breast cancer patient

Method for preparing androgen receptor-dependent breast cancer cell line, screening method using the cell line, and determination method, kit and marker for obtaining dependence on androgen receptor activity in breast cancer patient

机译：制备雄激素受体依赖性乳腺癌细胞系的方法，使用该细胞系的筛选方法以及获得乳腺癌患者对雄激素受体活性的依赖性的测定方法，试剂盒和标记物

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摘要

The problem to be solved by the present invention is to provide a cell line having a novel resistance mechanism completely different from conventional hormone therapy resistance mechanism, to provide a screening method using the cell line, to provide a breast cancer patient Has acquired such a resistance mechanism as to whether or not it has acquired the tolerance mechanism. TECHNICAL FIELD The present invention relates to a method for preparing a androgen receptor activity-dependent breast cancer cell, comprising the step of culturing T47D-TE8 cells in an estrogen-depleted medium and in the presence of androgen, a screening method using the breast cancer cell , And at least one selected from the group consisting of KLK3, DDC and AR as an indicator, for determining the presence or absence of androgen receptor activity dependence in breast cancer patients.

机译：本发明要解决的问题是提供一种具有与常规激素疗法耐药机制完全不同的新型耐药机制的细胞系，提供使用该细胞系的筛选方法，以提供获得这种耐药性的乳腺癌患者。是否已获得公差机制。雄激素受体活性依赖性乳腺癌细胞的制备方法技术领域本发明涉及一种雄激素受体活性依赖性乳腺癌细胞的制备方法，其包括在雌激素缺乏的培养基中，在雄激素存在下培养T47D-TE8细胞的方法，使用该乳腺癌的筛选方法。细胞，以及选自KLK3，DDC和AR的至少一种作为指示剂，用于确定乳腺癌患者中雄激素受体活性依赖性的存在与否。

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公开/公告号JPWO2014188775A1

专利类型
公开/公告日2017-02-23

原文格式PDF
申请/专利权人国立大学法人東北大学;
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申请/专利号JP20150518133
发明设计人林慎一;藤井里圭;
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申请日2014-03-25
分类号C12Q1/04;C12Q1/68;C07K14/72;C12N15/09;C12N5/09;G01N33/68;G01N33/50;G01N33/15;A61K45;A61K35;
国家 JP
入库时间 2022-08-21 13:54:18

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