The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to MuVIowa/us/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔSH) and/or incapable of expressing the V protein (rMuVΔV).
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机译：本发明提供了流行性腮腺炎病毒（MuV）毒株MuVIowa / us / 06的完整基因组序列。此外，构建了反向遗传学系统，并用于挽救与MuVIowa / us / 06和JL疫苗病毒相比减毒的重组病毒构建体。这样的构建体包括缺乏SH基因的开放阅读框（ORF）（rMuVΔSH）和/或不能表达V蛋白（rMuVΔV）的病毒构建体。
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