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Composition, method and kit for diagnosis of pancreatic / gastrointestinal neuroendocrine neoplasm

机译:诊断胰腺/胃肠道神经内分泌肿瘤的组合物,方法和试剂盒

摘要

Method for diagnosing, detecting or prognosing GEP-NEN based on the expression level score of a biomarker that exhibits differential expression in a subject with GEP-NEN compared to a reference or control sample I will provide a. The present invention also includes compositions and kits comprising these biomarkers, and methods of using these biomarkers in subsets or panels thereof to diagnose, classify, and monitor the types of GEP-NEN and GEP-NEN. provide. The methods and compositions provided herein are for distinguishing between different stages of GEP-NEN, such as stable GEP-NEN or progressive GEP-NEN, in order to diagnose or classify a subject as having GEPEN. It can also be used to obtain a measure of the risk of developing advanced GEP-NEN and to determine the completeness of treatment of GEP-NEN, including but not limited to surgery and somatostatin therapy.
机译:本发明提供一种基于生物标志物的表达水平得分来诊断,检测或预测GEP-NEN的方法,该生物标志物在与参考或对照样品相比具有GEP-NEN的受试者中表现出差异表达。本发明还包括包含这些生物标志物的组合物和试剂盒,以及在其亚组或组中使用这些生物标志物来诊断,分类和监测GEP-NEN和GEP-NEN的类型的方法。提供。本文提供的方法和组合物用于区分GEP-NEN的不同阶段,例如稳定的GEP-NEN或进行性GEP-NEN,以便将受试者诊断或分类为患有GEPEN。它也可用于获得发展晚期GEP-NEN的风险的度量,并确定GEP-NEN治疗的完整性,包括但不限于手术和生长抑素疗法。

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