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Early lung cancer detection method by DNA methylation phenotype determination of sputum-derived cells
Early lung cancer detection method by DNA methylation phenotype determination of sputum-derived cells
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机译：DNA甲基化表型测定痰标本细胞的早期肺癌检测方法
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摘要
In certain embodiments, the present application discloses a method for detecting lung cancer. The method includes characterization of cells extracted from human sputum, a useful tissue substitute and source of upper airway cells that become cancerous early in the course of lung cancer development. The method includes staining the extracted cells with a fluorescent reporter that produces a specific pattern in the nucleus of the labeled cells, wherein the pattern can be visualized by light microscopy. This pattern is associated with a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development compared to normal respiratory cells.
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