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PRINTABLE MORPHOGENETIC PHASE-SPECIFIC CHITOSAN-CALCIUM-POLYPHOSPHATE SCAFFOLD FOR BONE REPAIR

机译:可修复的形态发生相专用的壳聚糖-钙-磷酸钙支架用于骨修复

摘要

This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone N tissue engineering, as a bio mimetic 3-phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression/activation of bone alkaline phosphatase (Phase 3: hydroxyapatite-biomineral.
机译:本发明涉及由羧甲基壳聚糖(CMC)和聚磷酸盐(polyP)形成的可印刷杂化材料的合成配方。两种聚合物都通过钙离子连接在一起。与藻酸盐组合的本发明的CMC-polyP材料是生物相容的,可生物降解的,并且可用于三维(3D)打印和3D细胞打印(生物打印)。通过暴露于钙离子而硬化的CMC-polyP支架具有形态上的活性,可用于骨骼N组织工程,是一种仿生的3相仿生支架,可模拟并诱导骨骼修复的基本阶段,包括血凝块形成和血小板。脱粒(生长因子和细胞因子的释放)(阶段1:起始阶段),碳酸钙生物种子形成(阶段2:成核)和骨碱性磷酸酶的表达/激活(阶段3:羟基磷灰石生物矿物质)。

著录项

  • 公开/公告号EP3171902A1

    专利类型

  • 公开/公告日2017-05-31

    原文格式PDF

  • 申请/专利权人 MÜLLER WERNER ERNST LUDWIG GEORG;

    申请/专利号EP20150748200

  • 发明设计人 MÜLLER WERNER ERNST LUDWIG GEORG;

    申请日2015-07-24

  • 分类号A61L27/20;A61L27/46;A61L27/52;A61L27/56;A61L27/58;C08L5/08;

  • 国家 EP

  • 入库时间 2022-08-21 14:03:22

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