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METHOD OF PREDICTING RESPONSE OF A HUMAN SUBJECT SUFFERING FROM MULTIPLE SCLEROSIS TO INTERFERON BETA, (IFN-BETA)
METHOD OF PREDICTING RESPONSE OF A HUMAN SUBJECT SUFFERING FROM MULTIPLE SCLEROSIS TO INTERFERON BETA, (IFN-BETA)
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机译:预测多发性硬化症至干扰素(IFN-BETA)的人类受试者反应的方法
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摘要
The present invention refers to a method of predicting response of a human subject to Interferon beta, (IFN-β), wherein the subject is suffering from Multiple Sclerosis (MS), and wherein the method comprises using, as an indicator, the percentage of CD5+ CD19+ CD45+ B cells over the total count of lymphocytes (CD45+ cells) in a biological sample originating from the human subject and the percentage of CD8+ CD45+ perforin+ T cells over the total count of lymphocytes (CD45+ cells) in a biological sample originating from the human subject, wherein if the percentage of CD5+ CD19+ CD45+ B cells over the total count of lymphocytes (CD45+ cells) is lower than or equal to 3% and/orthe percentage of CD8+ CD45+ perforin+ T cells over the total count of lymphocytes (CD45+ cells) is greater than or equal to 1%, is indicative of response.
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