METHOD FOR ANALYZING A SAMPLE WITH A NON-LINEAR MICROSCOPY TECHNIQUE AND NON-LINEAR MICROSCOPE ASSOCIATED

• 1. 非线性显微镜及非线性观察方法 [P] . 中国专利： CN103415765B . 2017.03.22
• 2. 非线性显微镜及非线性观察方法 [P] . 中国专利： CN103415765A . 2013-11-27
• 3. Method for analyzing a sample with a non-linear microscopy technique and non-linear microscope associated [P] . 美国专利： US10191268B2 . 2019-01-29

  机译： 用非线性显微镜技术分析样品的方法及相关的非线性显微镜

• 4. METHOD FOR ANALYZING A SAMPLE WITH A NON-LINEAR MICROSCOPY TECHNIQUE AND NON-LINEAR MICROSCOPE ASSOCIATED [P] . 美国专利： US2017242232A1 . 2017-08-24

  机译： 非线性显微镜技术和非线性显微镜相结合的样品分析方法

• 5. METHOD FOR ANALYZING A SAMPLE WITH A NON-LINEAR MICROSCOPY TECHNIQUE AND NON-LINEAR MICROSCOPE ASSOCIATED [P] . 世界知识产权组织专利： WO2016059158A1 . 2016-04-21

  机译： 非线性显微镜技术和非线性显微镜相结合的样品分析方法

• 1. A Method on Non-Linear Correction of Broadband LFMCW Signal Utilizing Its Relative Sweep Non-Linear Error [J] . 系统工程与电子技术（英文版） . 2001,第001期
• 2. Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by non-linear response surface method incorporating multivariate spline interpolation. [J] . Arai H, Suzuki T, Kaseda C, Chemical and Pharmaceutical Bulletin . 2007,第4期
• 3. Analyzing driving factors of land values in urban scale based on big data and non-linear machine learning techniques [J] . Land Use Policy . 2020,第期
• 4. Applications of non-linear imaging microscopy techniques to cultural heritage objects [J] . Mari M., Tsafas V., Melessanaki K., Insight . 2018,第12期
• 5. Applied of look up table controller based of FLC (fuzzy logic controller) in non-linear system AFM (atomic force microscopy)/PSTM (photon scanning tunnel microscope) [C] . Ari, S., Belier, . 2002
• 6. Design and development of non-linear optical microscopy, data acquisition and analysis techniques. [D] . Sullivan, Shane Z. 2015
• 7. Penaeus orientolis prawn freshness rapid determination method based on electronic nose and non-linear stochastic resonance technique [O] . Liu Wei, Han Yuanyuan, Cai Yanping, 2015
• 8. Sub-diffraction imaging on standard microscopes through photobleaching microscopy with non-linear processing [O] . Munck, Sebastian, Miskiewicz, Katarzyna, Sannerud, Ragna, 2012

• 1. Non-Linear Analysis of Vibrations of Non-Linear System Subjected to Multi-Excitation Forces via a Non-Linear Absorber [J] . Taha H. El-Ghareeb ,Yaser S. Hamed ,Mohamed S. Abd Elkader . 应用数学（英文） . 2012,第1期
• 2. Software Defect Prediction Based on Non-Linear Manifold Learning and Hybrid Deep Learning Techniques [J] . Kun Zhu ,Nana Zhang ,Qing Zhang . 计算机、材料和连续体(英文) . 2020,第11期
• 3. Modified Adomian Techniques Applied to Non-Linear Volterra Integral Equations [J] . Haifa H. Ali ,Fawzi Abdelwahid . 应用科学（英文） . 2013,第2期
• 4. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 5. 基于DSP的扫描探针显微镜中压电陶瓷管非线性校正技术及其实现 [C] . 刘辉 ,黄自元 ,费敏锐 . 全国冶金自动化信息网2003年年会 . 2003
• 6. 原子力显微镜中压电陶瓷管非线性校正技术实现与研究 [A] . 刘辉 . 2004