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HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE

机译:HIV-1母婴传播与保护和疫苗的相关性

摘要

The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
机译:本发明提供了在需要其的受试者中诱导和增强抗体应答的组合物和方法,所述抗体应答包括但不限于与HIV-1结合的IgG应答,其中所述抗体应答的诱导/增强血浆水平,例如V3和/或CD4结合位点抗体反应超过阈值水平,并且与HIV-1的母婴传播(MTCT)风险降低有关。

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