首页> 外国专利> MODULATING EPIGENETIC DNA METHYLATION TO CAUSE CELLS TO ADOPT DNA METHYLATION PATTERNS ASSOCIATED WITH YOUNG CELLS

MODULATING EPIGENETIC DNA METHYLATION TO CAUSE CELLS TO ADOPT DNA METHYLATION PATTERNS ASSOCIATED WITH YOUNG CELLS

机译:调节表位的DNA甲基化导致细胞适应与年轻细胞相关的DNA甲基化模式

摘要

Disclosed herein is a topical composition that contains (a) a plant meristem conditioned nutrient medium derived from the plants of the genus Oryza; (b) a preservative present at an amount sufficient to provide sterilizing or biostatic efficacy with respect to component (a); and (c) a dermatologically acceptable vehicle. When topically applied to mammalian cells, the composition of the invention can influence the epigenetic methylation of the DNA such that the methylation state is modulated to have more characteristics and patterns of the epigenetic state of younger cells.
机译:本文公开了一种局部用组合物,其包含(a)衍生自稻属植物的植物分生组织条件养分培养基; (b)防腐剂的存在量足以提供相对于组分(a)的杀菌或抑菌功效; (c)皮肤病学可接受的载体。当局部应用于哺乳动物细胞时,本发明的组合物可以影响DNA的表观遗传甲基化,使得甲基化状态被调节为具有年轻细胞的表观遗传状态的更多特征和模式。

著录项

  • 公开/公告号EP2691073B1

    专利类型

  • 公开/公告日2017-05-31

    原文格式PDF

  • 申请/专利权人 ARCH CHEMICALS INC.;

    申请/专利号EP20120710725

  • 申请日2012-03-26

  • 分类号A61K8/34;A61K8/36;A61K8/368;A61K8/66;A61Q19/08;A61K8/97;A61K8/49;

  • 国家 EP

  • 入库时间 2022-08-21 14:05:51

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