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MOLECULAR SIGNATURE OF CUTANEOUS PIGMENT TASKS ASSOCIATED WITH REMODELING THE EXTRACELLULAR MATRIX
MOLECULAR SIGNATURE OF CUTANEOUS PIGMENT TASKS ASSOCIATED WITH REMODELING THE EXTRACELLULAR MATRIX
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机译：重塑细胞外基质相关的皮肤色素任务的分子特征
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摘要
Method of characterization of skin pigment spot apparent or suspected in a human, comprises comparing expression levels, in skin samples form the spot and unwounded adjacent skin, of at least a dermal gene involved in the remodeling of the extracellular matrix, comprising MXRA5, LYZ, CTSL2, PLAU or TIMP1 genes. Independent claims are included for: (1) a method of evaluating the efficacy of a treatment of skin pigment spots comprising comparing expression levels, in skin samples form the spot after such a spot, before and after treatment, of the dermal gene; (2) an in vitro method for evaluating the efficacy of a treatment of skin pigment spots, comprising comparing, before and after treatment, the level of expression in a representative cellular model of the skin, of the dermal gene or the level of expression or activity of the expression product of the selected gene; (3) cosmetic method of treatment or prevention of skin pigment spot of non-pathological human skin comprising modulating the level of expression or activity of the gene, where the modulation is effected through the use of an antisense molecule, an small interfering (si)RNA, a microRNA or a plant extract of Lupinus albusLU10; (4) use of a modulator of the expression level or activity of the expression product of the gene, for cosmetic applications in the treatment of non-pathological skin pigment spots, where the modulator is an antisense molecule, siRNA, a microRNA, a plant extract of Lupinus albusLU10, polypeptide for activating pituitary adenylate cyclase, valsartan, demineralized bone powder, sodium phenylacetate, P-aminobenzamidine, 4-substituted benzo [b] thiophene-2 -carboxamidine (B428), thienopyridine (SR 25989) or notoginsenoside R1; and (5) a modulator of the expression level or activity of the expression product of the dermal gene. ACTIVITY : Dermatological. MECHANISM OF ACTION : Gene expression modulator.
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