首页> 外国专利> DIAGNOSTIC TECHNIQUE FOR DISPOSITION TO ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASES BY PERIPHERAL BLOOD INTERLEUKIN-10-PRODUCING LYMPHOCYTE COUNT

DIAGNOSTIC TECHNIQUE FOR DISPOSITION TO ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASES BY PERIPHERAL BLOOD INTERLEUKIN-10-PRODUCING LYMPHOCYTE COUNT

机译：通过外周血白细胞介素-10产生的淋巴细胞计数诊断慢性缺血性心脏病患者的动脉粥样硬化进展的诊断技术

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FIELD: medicine.;SUBSTANCE: invention represents a diagnostic technique for a disposition to atherosclerosis progression in patients with chronic ischemic heart disease involving sample analysis to measure an interleukin-10-producing T-lymphocyte count, characterised by recovering a mononuclear cell fraction from the peripheral blood, activating the cells in a culture, conducting lymphocyte phenotyping with the use of fluorescent anti-CD4 and interleukin-10 (IL-10) antibodies, and performing flow cytometry; the IL-10-producing T-lymphocyte (CD4+IL-10+ cell) count expressed as a percentage (%) of CD4+ lymphocytes of less than 3.5% is indicative of the high risk of atherosclerosis progression.;EFFECT: higher effectiveness of a method for detecting the patients prone to atherosclerosis progression.;2 ex

机译：发明领域：本发明代表一种用于诊断患有慢性缺血性心脏病的患者的动脉粥样硬化进展的诊断技术，该技术涉及样品分析以测量产生白介素10的T淋巴细胞计数，其特征在于从中回收单核细胞部分。外周血，激活培养物中的细胞，使用荧光抗CD4和白介素10（IL-10）抗体进行淋巴细胞表型分析，并进行流式细胞术;产生IL-10的T淋巴细胞（CD4 + IL-10 +细胞）计数，以CD4 +淋巴细胞的百分比（％）小于3.5％表示动脉粥样硬化进展的高风险。一种检测患者容易发生动脉粥样硬化进展的方法。; 2 ex

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公开/公告号RU0002575791C1

专利类型
公开/公告日2016-02-20

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申请/专利号RU2014141098/15
发明设计人 КРАСНИКОВА ТАТЬЯНА ЛЕОНИДОВНА (RU);ПЫЛАЕВА ЕКАТЕРИНА АЛЕКСЕЕВНА (RU);РУЛЕВА НАТАЛЬЯ ЮРЬЕВНА (RU);ПОТЕХИНА АЛЕКСАНДРА ВИКТОРОВНА (RU);НОЕВА ЕЛЕНА АЛЕКСАНДРОВНА (RU);ПРОВАТОРОВ СЕРГЕЙ ИЛЬИЧ (RU);БАЛАХОНОВА ТАТЬЯНА ВАЛЕНТИНОВНА (RU);АРЕФЬЕВА ТАТЬЯНА ИГОРЕВНА (RU);
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申请日2014-10-13
分类号G01N33/50;
国家 RU
入库时间 2022-08-21 14:11:02

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