METHOD rehabilitation of children with gastroduodenal pathology on sanatorium STAGE

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• 3. METHOD FOR SANATORIUM-RESORT REHABILITATION OF CHILDREN WITH GASTRODUODENAL PATHOLOGY [P] . UA71559U . 2012-07-10

  机译： 十二指肠病理学的儿童对儿童进行疗养院修复的方法

• 4. METHOD Musculo-skeletal pathology in children with juvenile rheumatoid arthritis for sanatorium STAGE [P] . 俄罗斯专利： RU161719U1 . 2016-04-27

  机译： 方法对儿童类风湿关节炎的儿童骨骼肌病理进行疗养

• 5. METHOD FOR TREATING CHILDREN WITH THYROID PATHOLOGY IN SANATORIUM STAGE OF TREATMENT [P] . UA17095U . 2006-09-15

  机译： 治疗疗养期甲状腺疾病的方法

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• 5. TEST PERFORMANCE OF PSYCHOTIC CHILDREN WITH ORGANIC BRAIN PATHOLOGY: A STUDY TO DETERMINE WHETHER THE BENDER-GESTALT TEST, THE BENTON VISUAL RETENTION TEST, AND THE MARBLE BOARD TEST CAN DETECT THE PRESENCE OF ORGANIC BRAIN PATHOLOGY IN PSYCHOTIC CHILDREN. [D] . MATUNAS, MARIAN ISABEL. 1960
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• 1. Augev Method and an Innovative Use of Vocal Spectroscopy in Evaluating and Monitoring the Rehabilitation Path of Subjects Showing Severe Communication Pathologies [J] . Antonia Campanella ,Fabio Manca ,Claudia Marin . 临床医学国际期刊（英文） . 2019,第2期
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• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage [J] . Masahiro Iizuka ,Taku Harada ,Hiro-o Yamano . 世界胃肠内镜杂志：英文版（电子版） . 2012,第3期
• 5. Application of Optical Methods in Blood Studies upon Evaluation of Severity Rate of Diffuse Liver Pathology [J] . Margarita Kruchinina ,Mikhail Voevoda ,Sergey Peltek . 分析科学方法和仪器期刊（英文） . 2013,第2期
• 6. 慢性胃炎的纤维胃十二指肠镜及病理检查与人的类型对比的研究 [C] . 吕跃 . 中华医学会消化系病第三次全国学术会议 . 1987
• 7. 幽门螺杆菌感染对儿童胃十二指肠黏膜相关微生物菌群的影响及其致病机制 [A] . 郑伟 . 2019