首页> 外国专利> METHOD FOR FORECASTING RISK OF DEVELOPMENT OF MALIGNANT NOVOGRAPHY OR DIAGNOSIS OF MALIGNANT NOVOLEMENTATION IN A SPECIAL FEMALE

METHOD FOR FORECASTING RISK OF DEVELOPMENT OF MALIGNANT NOVOGRAPHY OR DIAGNOSIS OF MALIGNANT NOVOLEMENTATION IN A SPECIAL FEMALE

机译:预测女性恶性摄影术发展风险或恶性发展的诊断方法

摘要

1. A method for predicting the risk of developing a malignant neoplasm in a female individual that does not suffer from a malignant neoplasm, comprising: - determining the level of pro-neurotensin 1-117 or fragments thereof from at least 5 amino acids or pro-neurotensin 1-117 containing peptides , in biological fluid obtained from the indicated female; and - correlation of the indicated level of pro-neurotensin 1-117 or its fragments or pro-neurotensin 1-117 containing peptides with a risk of developing malignant neoplasm, where an increased level is prognostic for an increased risk of developing malignant neoplasm and, where said malignant neoplasm is selected from breast cancer, lung cancer, pancreatic cancer, and colon cancer. 2. The method of claim 1, wherein said malignant neoplasm is breast cancer. The method of claim 1 or 2, wherein the elevated level denotes a level above a threshold level. A method according to claim 1 or 2, wherein the level of pro-neurotensin 1-117 or fragments thereof of at least 5 amino acids or pro-neurotensin 1-117 containing peptides in the biological fluid is an empty stomach. The method of claim 1 or 2, wherein in said female, a malignant neoplasm has never been previously diagnosed during sampling of a biological fluid from said female. The method according to claim 1 or 2, wherein a malignant neoplasm was diagnosed in the indicated female and was cured during the sampling of the biological fluid from the indicated female, and the risk of relapse is determined
机译:1.一种用于在未患有恶性肿瘤的女性个体中预测发展为恶性肿瘤的风险的方法,其包括:-从至少5个氨基酸或前体确定神经降压素1-117或其片段的水平。 -从所指示的雌性获得的生物流体中含有-神经降压素1-117的肽;以及-指示的神经紧张素原1-117或其片段或神经营养素原1-117的肽水平与发展为恶性肿瘤的风险相关,其中升高的水平预示了发展为恶性肿瘤的风险增加,并且,其中所述恶性肿瘤选自乳腺癌,肺癌,胰腺癌和结肠癌。 2.权利要求1的方法,其中所述恶性肿瘤是乳腺癌。 3.根据权利要求1或2所述的方法,其中,所述升高的水平表示高于阈值水平的水平。 3.根据权利要求1或2所述的方法,其中,所述生物体液中的神经紧张素原1-117或其片段的至少5个氨基酸或含有肽的神经紧张素原1-117的水平为空腹。 3.根据权利要求1或2所述的方法,其中在所述雌性中,从未从所述雌性中取样生物流体的过程中事先诊断出恶性肿瘤。 3.根据权利要求1或2所述的方法,其中,在所述指示的雌性中诊断出恶性肿瘤并且在从所述指示的雌性中取样生物流体的过程中将其治愈,并且确定了复发的风险。

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