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epithelialmesenchymal transition EMT Cell culture substrate for inducing epithelialmesenchymal transition use thereof and preparing the same
epithelialmesenchymal transition EMT Cell culture substrate for inducing epithelialmesenchymal transition use thereof and preparing the same
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机译:上皮间质转化EMT细胞培养基质,用于诱导其上皮间质转化的用途及其制备方法
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摘要
The present invention relates to a cell culture substrate for epithelial-mesenchymal transition (EMT) induction, wherein a columnar structure having a certain average diameter including a flat surface on which cells are adhered and cultured on the upper part, Wherein the columnar structure is controlled to have a distance from the center of one column to the center of the adjacent column of 4 占 퐉 to 30 占 퐉; A drug screening method using the cell culture substrate; A method for screening a patient-customized anticancer agent and fibrosing agent comprising the step of treating the cell culture substrate with cells isolated from the cancer tissue of the patient by treating or non-treating the anticancer agent candidate substance; And a step of preparing an intermediate mold comprising a plurality of columnar structures comprising an intaglio-patterned elastic polymer.
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