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METHODS AND COMPOSITIONS FOR TREATING CANCERS HAVING ACQUIRED RESISTANCE TO CHEMOTHERAPEUTIC AND TARGETED DRUGS USING CARBOXYAMIDOTRIAZOLE OROTATE
METHODS AND COMPOSITIONS FOR TREATING CANCERS HAVING ACQUIRED RESISTANCE TO CHEMOTHERAPEUTIC AND TARGETED DRUGS USING CARBOXYAMIDOTRIAZOLE OROTATE
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机译:使用羧酰胺基三唑乳清酸盐治疗对化疗药物和靶向药物具有耐药性的治疗方法和组合物
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摘要
The present invention provides methods and compositions useful for treating early and late stage metastatic cancers for preventing or treating acquired resistance due to gene amplification or mutation in response to chemotherapeutic agents and / or targeted drugs. In particular, the methods and compositions include carboxyamidotriazole oerate (CTO) alone or in combination with a chemotherapeutic and / or targeted drug of a specific regimen designed to overcome the genomic resistance raised for prior therapy therapies do.
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