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PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, CONTAINING HUMAN BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AS ACTIVE INGREDIENT
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, CONTAINING HUMAN BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AS ACTIVE INGREDIENT
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机译:预防或治疗自身免疫性疾病的药物组合物,其中包含人骨骨髓间充质干细胞作为活性成分
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摘要
The present invention provides a pharmaceutical composition for preventing or treating autoimmune diseases, containing human bone marrow-derived mesenchymal stem cells as an active ingredient. The human bone marrow-derived mesenchymal stem cells of the present invention exhibit prophylactic or therapeutic efficacy on autoimmune diseases by having no toxicity, suppressing the generation of anti-dsDNA antibodies, proteinuria, and total IgG, inhibiting the proliferation of T cells and B cells, and inhibiting cytokine expression of T cells. Lupus causes inflammation in the kidney by autoantibodies and immune complexes, and increases the infiltration of immune cells, and the administration of the human bone marrow-derived mesenchymal stem cells of the present invention reduces the infiltration of immune cells into the kidney, thereby exhibiting a prophylactic or therapeutic effect on the lupus.
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