首页> 外国专利> POLYMER-METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME

POLYMER-METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME

机译:具有MRI对比能力和使用相同的MRI对比和/或反面成分的聚合物复合材料

摘要

The present invention provides a polymer-metal complex composite, whichcomprises a block copolymer capable of serving as a constituent member of apolymericmicelle and a metal complex having MRI contrast ability, accumulates in atumor--specificmanner, achieves high image contrast even in a small amount, and has reducedside effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises ablock copolymer (A) represented by general formula (a) and a metal complex (B)having MRI contrast ability, wherein the composite comprises a structure inwhich acarboxyl anion of poly(carbo) in the copolymer (A) is attached to the metalcomplex (B)via a metal atom (M).
机译:本发明提供了一种聚合物-金属络合物复合材料,其中包含能够用作聚合物的组成成员的嵌段共聚物聚合胶束和具有MRI对比功能的金属络合物堆积在肿瘤特异性方式,即使少量也可以实现高图像对比度,并且降低了副作用以及在血液中的保留时间长。本发明的聚合物-金属配合物复合物包含通式(a)表示的嵌段共聚物(A)和金属配合物(B)具有MRI对比能力的复合材料,其中复合材料包含哪一个共聚物(A)中聚(碳)的羧基阴离子连接到金属上复合(B)通过金属原子(M)。

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