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Procedure to identify patients with mild cognitive disorders who need therapy and treatment of patients of this type
Procedure to identify patients with mild cognitive disorders who need therapy and treatment of patients of this type
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机译：识别需要治疗和治疗的轻度认知障碍患者的程序
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摘要
In vitro procedure for risk stratification of patients with mild cognitive disorders in order to identify patients with mild cognitive disorders that need therapy, comprising - determining at least one peptide biomarker relevant to circulation in a sample of a biological fluid from of the circulation of a patient diagnosed with a mild cognitive disorder, and - associating an increased risk for the development of a clinically manifest neurodegenerative disease with an increased concentration for said at least one peptide biomarker relevant to circulation, found by above a specific threshold value for the biomarker (cut-off) in the range of usual concentration values for these biomarkers in the case of mild cognitive disorders, the biomarker being relevant for circulation selected from the MR-proANP and / or MR-proADM, and the value being threshold for MR-ProANP 60 - 90 pmol / l and the threshold value for MR-ProADM 0.5 - 0.7 nmol / l, and patients with the established higher risk identified as needing therapy for treatment with a drug, comprising one or more active ingredients of cardiovascular agents selected from the group consisting of: ANP receptor antagonists, adenosine receptor antagonists, ACE inhibitors, angiotensin II receptor antagonists, beta-blockers and diuretics that reduce blood pressure and their combinations, to delay or prevent the development of clinically manifest neurodegenerative disorders or to improve or maintain the state of mild cognitive disorder.
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