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eps22 exopolysaccharide of pseudomonas stutzeri as22 having antioxidant activity and heal

机译：斯图氏假单胞菌as22的eps22胞外多糖具有抗氧化活性和修复作用

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the present invention describes the production and purification of extracellular polysaccharide, named eps22, produced by a strain of pseudomonas stutzeri as22, isolated from soil in the region of sfax. it also relates to the use of this substance in the field cosmu00e9to pharmaceutical as a wound healing agent.more specifically, it describes the evaluation in a rat experimental model of business model, the eps22 heal skin wounds on the mechanically induced wound healing in comparison with a reference, the cicaflorau00bb.our interest in the application of the eps22 is motivated by its structural characteristics but also its appearance of gel and its antioxidant power quite interesting. the structural analysis shows that there is a hu00e9tu00e9ropolysaccharide, high molecular weight, highly acetylated and the glucose and mannose sugars constituting the majority.the rheological characterization showed that the eps22 of this invention has a gelling power, and is present in a concentration of 0.5% in the form of a gel to useful mechanical properties. this feature it is an asset for a u00e9ventuelie application in the formulation of the gels for dermatological use.the identification, in vitro antioxidant activities on some tests of dpph, reducing power and chelating showed a protective effect against oxidative stress, could enhance the repair process of wound healing.evaluation in vivo in a rat experimental model of business model, the eps22 heal, applied in the form of a gel, mechanically induced wounds on the skin wound healing agent, has shown a promising.the results obtained with the chromaticity and histological analysis showed a complete closure of the wounds treated with the hydrogel eps22 after 12 days with a tissue regeneration step, characterized by the presence of strata, well organized and the epi dermis the dermis.
机译：本发明描述了由斯图克斯假单胞菌as22菌株分离并从斯法克斯地区的土壤中分离得到的名为eps22的细胞外多糖的生产和纯化。它还涉及该物质在宇宙制药领域作为伤口愈合剂的用途。更具体地说，它描述了在商业模式的大鼠实验模型中评估eps22愈合皮肤在机械诱导的伤口愈合中的作用。与参考文献相比，cicaflora对我们在eps22中的应用的兴趣是由其结构特性，凝胶的外观和抗氧化能力引起的。结构分析表明存在ah u00e9t u00e9ro多糖，高分子量，高度乙酰化，并且葡萄糖和甘露糖糖占多数。流变学特性表明，本发明的eps22具有胶凝能力，并且以一定浓度存在。 0.5％的凝胶形式对有用的机械性能。此特性对于在皮肤病学凝胶配方中的应用而言是一项资产。鉴定，体外某些dpph测试的抗氧化活性，降低功率和螯合表现出对氧化应激的保护作用，可以增强修复作用伤口愈合的过程。在商业模型的大鼠实验模型中的体内评估，以凝胶形式应用的eps22愈合，以机械方式在皮肤伤口愈合剂上诱导伤口，已显示出令人鼓舞的结果。通过色度获得的结果组织学分析显示，经过12天的组织再生步骤，用水凝胶eps22处理的伤口完全闭合，其特征是存在分层，组织良好以及真皮表皮。

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