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METHOD FOR EXTRACTION OF ANTIBACTERIAL ELLAGIC ACID TOWARDS MECHANISTIC ACTION AGAINST PROTEINS FROM MDR ISOLATES
METHOD FOR EXTRACTION OF ANTIBACTERIAL ELLAGIC ACID TOWARDS MECHANISTIC ACTION AGAINST PROTEINS FROM MDR ISOLATES
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机译：从抗微生物药分离物中提取抗菌肽对蛋白质作用机理的方法
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ABSTRACT Urinary tract infections (UTIs) are common infections that usually occur when bacteria enter the opening of the urethra and multiply in the urinary tract. The urinary tract includes the kidneys, ureters, bladder, and urethra. Urinary tract infections usually develop first in the lower urinary tract (urethra, bladder) and, if not treated, progress to the upper urinary tract (ureters, kidneys). The present invention relates to method of extraction of organic compound Ellagic acid for treatment of Multidrug- resistant Urinary Tract Infection using extract of fresh leaves of Andrographispaniculata (Burm. f.) Nees, Asteracantha Longifolia(L.) Nees, Bixaorellana L., Gardenia resinifera Roth, Pongamiapinnata(L.)Pierre, Psoraleacorylifolia L., Solanumtrilobatum L., Soymida Febrifuga(Roxb.)Juss, Sphaeranthus Indicus Linnaeus And Thespesia Populnea(L.)Sol.ex Correa. The antibacterial potential of the extracted Ellagic acid has been proved by its efficacy to inhibit the -lactamase activity (OXA and AmpC) and binding to the active site of PBP of the is lated MDR-UTI pathogen E. colias analyzed with biological as well as molecular docking tools.
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