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DEVELOPMENT OF GRAPHENE OXIDE INCORPORATED POLYSACCHARIDE AND HYDROXYAPATITE BASED TRI-COMPONENT COMPOSITE SCAFFOLDS AND STUDY OF THEIR OSTEOCONDUCTIVITY ON MG-63 CELL LINE
DEVELOPMENT OF GRAPHENE OXIDE INCORPORATED POLYSACCHARIDE AND HYDROXYAPATITE BASED TRI-COMPONENT COMPOSITE SCAFFOLDS AND STUDY OF THEIR OSTEOCONDUCTIVITY ON MG-63 CELL LINE
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机译：氧化石墨烯复合多糖和羟基磷灰石基三组分复合支架的研制及其在MG-63细胞株上的骨电导率研究
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摘要
Regenerative medicine witness a paradigm shift from synthetic implants and tissue grafts to a tissue engineering approach that incorporates biodegradable, bioceramic composite scaffolds with biological cells. A combination of carbon nanomaterials and hydroxyapatite with polysaccharides hold a great potential in bone tissue engineering. In the present study, new tri-component composite scaffolds of graphene oxide (GO)-gellan-hydroxyapatite (HAP), GO-alginate-HAP and GO-amylopectin-HAP was prepared by freeze drying method in order to achieve the required porosity. FTIR and XRD results of the scaffolds confirmed the ionic interaction between the individual components and formation of composite. FE-SEM images showed the porous morphology of scaffolds. In vitro MTT assay of scaffolds on MG 63 cell line proves its osteoconductivity and biocompatibility. Alkaline phosphatase (ALP) activity proves the increasing mineralization. Among the scaffolds prepared, GO-amylopectin-HAP exhibited higher biocompatibility, ALP activity and cell attachment due to higher pore size and porosity. The in vitro results suggest that the prepared tri-component scaffold can be used as promising biomaterials in tissue engineering.
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