首页>
外国专利>
SYNTHESIS, MOLECULAR DOCKING AND ANTIDIABETICS STUDIES OF NOVEL DIHYDROPYRIMIDO 4,5-AACRIDIN-2-AMINES
SYNTHESIS, MOLECULAR DOCKING AND ANTIDIABETICS STUDIES OF NOVEL DIHYDROPYRIMIDO 4,5-AACRIDIN-2-AMINES
展开▼
机译：新型[4,5-A] AC啶-2-胺的合成，分子对接和抗糖尿病研究
展开▼
页面导航
摘要
著录项
相似文献
摘要
Synthesis, molecular docking and antidiabetic studies of novel dihydropyrimido[4,5-a]acridin-2-amines In the preceding study, a series of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines, 3a-f have been synthesized. Structures of these synthesized molecules were studied by FT-IR, [U NMR, nC NMR, EI-MS and single crystal X-ray structural analysis data. An in silico molecular docking was performed on derivatives of highest in vitro activity on a-amylase and a-glucosidase. Overall data indicate that the compound 3e is a promising lead compound for the development of selective inhibition of a-amylase and a-glucosidase. The synthesized compounds were screened for their antidiabetic activity by in vitro methods.
展开▼
