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首页> 外国专利> METHOD FOR MEASURING GLYCOPROTEIN METHOD FOR EXAMINING LIVER DISEASE REAGENT FOR QUANTITATIVE DETERMINATION OF GLYCOPROTEIN AND GLYCAN- MARKER GLYCOPROTEIN AS AN INDEX FOR CLINICAL CONDITIONS OF LIVER DISEASE

METHOD FOR MEASURING GLYCOPROTEIN METHOD FOR EXAMINING LIVER DISEASE REAGENT FOR QUANTITATIVE DETERMINATION OF GLYCOPROTEIN AND GLYCAN- MARKER GLYCOPROTEIN AS AN INDEX FOR CLINICAL CONDITIONS OF LIVER DISEASE

机译：糖蛋白测定方法测定肝病病原体定量测定肝病临床症状指标中的糖蛋白和甘聚糖标记的糖蛋白

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摘要

An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a reagent for quantitative determination of a glycoprotein, which is used for the above measurement methods. Furthermore, an object of the present invention is to provide a glycan-marker glycoprotein as an index for clinical conditions of liver disease, which is capable of identifying the clinical conditions of liver disease depending on the progress of liver disease. The method for measuring a glycoprotein is characterized in that: the glycoprotein is at least one glycoprotein selected from alpha-1-acid glycoprotein (AGP) and Mac-2-binding protein (M2BP) contained in a sample collected from a subject; when the glycoprotein is AGP, AGP binding to a first lectin selected from AOL and MAL is measured; and when the glycoprotein is M2BP, M2BP binding to a second lectin selected from WFA, BPL, AAL, RCA120, and TJAII is measured.
机译：本发明的目的是提供一种测量聚糖标记糖蛋白的方法，与常规方法相比，通过该方法可以以更高的准确性检测肝脏疾病。另外，本发明的目的是提供一种检查肝脏疾病的方法，通过该方法可以比传统方法更准确地检测肝脏疾病。另外，本发明的目的是提供一种定量测定糖蛋白的试剂，其用于上述测量方法。此外，本发明的目的是提供作为肝病临床状况指标的聚糖标记糖蛋白，其能够根据肝病的进展来鉴定肝病临床状况。糖蛋白的测定方法的特征在于：糖蛋白是选自被检体的样品中所含的选自α-1-酸糖蛋白（AGP）和Mac-2-结合蛋白（M2BP）中的至少一种糖蛋白。当糖蛋白为AGP时，测定AGP与选自AOL和MAL的第一凝集素的结合;当糖蛋白为M2BP时，测量M2BP与选自WFA，BPL，AAL，RCA120和TJAII的第二凝集素的结合。

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