首页> 外国专利> Multivalent meningococcal polysaccharide- protein conjugate vaccine for use in protecting a human against infection by n. meningitidis, a method for preparing such a vaccine and a multivalent conjugate vaccine comprising four distinct and separately made protein-capsular polysaccharide conjugates

Multivalent meningococcal polysaccharide- protein conjugate vaccine for use in protecting a human against infection by n. meningitidis, a method for preparing such a vaccine and a multivalent conjugate vaccine comprising four distinct and separately made protein-capsular polysaccharide conjugates

机译：多价脑膜炎球菌多糖-蛋白结合疫苗，用于保护人类免受n。脑膜炎，一种制备这种疫苗的方法和一种多价结合疫苗，其包含四种不同的和分开制备的蛋白-荚膜多糖结合

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摘要

The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacterial Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults,

机译：本发明描述了一种联合疫苗，其对由致病性细菌脑膜炎奈瑟氏菌引起的脑膜炎球菌疾病提供广泛的保护。该疫苗由四种不同的多糖-蛋白质结合物组成，它们被配制成单剂疫苗。来自脑膜炎奈瑟氏球菌血清群A，C，W-135和Y的纯化荚膜多糖经过化学活化，并通过共价化学键选择性地附着到载体蛋白上，形成了多糖-蛋白缀合物，能够引起对多种细菌的长期免疫力以及儿童和成人中脑膜炎奈瑟氏球菌的种类，

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公开/公告号IL225522A

专利类型
公开/公告日2016-04-21

原文格式PDF
申请/专利权人 SANOFI PASTEUR INC.;
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申请/专利号IL20130225522
发明设计人
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申请日2013-04-02
分类号A61K39/05;A61K39/095;A61K47/48;A61P31/04;A61P37;A61P43;
国家 IL
入库时间 2022-08-21 14:26:02

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