首页> 外国专利> human antibody, bispecific molecule, expression vector, recombinant eukaryotic or prokaryotic host cell, pharmaceutical composition, use of the antibody or bispecific molecule, methods for inhibiting the development and / or proliferation of a tissue factor expressing tumor cell to produce an antibody, and to detect the presence of tissue factor in a sample, diagnostic composition, and kit to detect the presence of tissue factor in a sample.

human antibody, bispecific molecule, expression vector, recombinant eukaryotic or prokaryotic host cell, pharmaceutical composition, use of the antibody or bispecific molecule, methods for inhibiting the development and / or proliferation of a tissue factor expressing tumor cell to produce an antibody, and to detect the presence of tissue factor in a sample, diagnostic composition, and kit to detect the presence of tissue factor in a sample.

机译：人抗体，双特异性分子，表达载体，重组真核或原核宿主细胞，药物组合物，抗体或双特异性分子的用途，抑制表达组织因子的肿瘤细胞发育和/或增殖以产生抗体的方法，以及检测样品中组织因子的存在，诊断组合物和试剂盒以检测样品中组织因子的存在。

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摘要

Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

机译：公开了与人TF结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。还公开了包含抗体的药物组合物，以及使用该抗体的治疗和诊断方法。

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公开/公告号BRPI0922350A2

专利类型
公开/公告日2016-01-12

原文格式PDF
申请/专利权人 GENMAB A/S;
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申请/专利号BR2009PI22350
发明设计人 DAVID P. E. SATIJIN;EVA EHRNROOTH;JAN VAN DE WINKEL;MAROESKA OUDSHOORN;MISCHA HOUTKAMP;OLE BAADSGAARD;PAUL PARREN;RENE M. A. HOET;ROB N. DE JONG;SANDRA VERPLOEGEN;TOM VINK;VIBEKE MILLER BREINHOLT;WILLEM KAREL BLEEKER;
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申请日2009-12-09
分类号C07K16/36;A61P35;
国家 BR
入库时间 2022-08-21 14:26:46

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