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首页> 外国专利> fusion protein, polynucleotide, construct, vector, host cell or organism, pharmaceutical composition or vaccine, use of fusion protein, method for preventing or treating hev infection or diseases associated with hev infection, method for preventing or treating influenza virus infection and diseases associated with influenza virus infection, method for improving the immunogenicity of a target protein and use of crm197 or a fragment thereof

fusion protein, polynucleotide, construct, vector, host cell or organism, pharmaceutical composition or vaccine, use of fusion protein, method for preventing or treating hev infection or diseases associated with hev infection, method for preventing or treating influenza virus infection and diseases associated with influenza virus infection, method for improving the immunogenicity of a target protein and use of crm197 or a fragment thereof

机译：融合蛋白，多核苷酸，构建体，载体，宿主细胞或生物，药物组合物或疫苗，融合蛋白的用途，预防或治疗乙型肝炎病毒感染或与乙肝病毒感染有关的疾病，预防或治疗流感病毒感染的方法以及与乙肝病毒有关的疾病流感病毒感染，提高靶蛋白免疫原性的方法以及crm197或其片段的用途

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摘要

Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.
机译：本发明提供了白喉毒素无毒突变体CRM197或其片段作为融合蛋白中的佐剂，及其在增强与之融合的靶蛋白例如HEV衣壳蛋白，流感病毒M2蛋白或其免疫原性片段。还提供了增强靶蛋白的免疫原性的方法，该方法包括将CRM197或其片段与靶蛋白融合表达以形成融合蛋白。还提供了包含CRM197或其片段和靶蛋白的融合蛋白，所述CRM197或其片段增强了靶蛋白的免疫原性。本发明还提供了分离的编码融合蛋白的核酸，包含所述核酸的构建体和载体以及包含所述核酸的宿主细胞。

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