首页> 外国专利> stable micelle, pharmaceutical or cosmetic composition comprising stable micelle, method of preparing a stable micelle, method of treating a p-glycoprotein (p-gp) dependent multidrug resistant (mdr) drug for cancer, sustainable release method one or more charge molecules and stable micelle utilization

stable micelle, pharmaceutical or cosmetic composition comprising stable micelle, method of preparing a stable micelle, method of treating a p-glycoprotein (p-gp) dependent multidrug resistant (mdr) drug for cancer, sustainable release method one or more charge molecules and stable micelle utilization

机译：稳定胶束，包含稳定胶束的药物或化妆品组合物，制备稳定胶束的方法，治疗癌症的p-糖蛋白（p-gp）依赖性多药耐药（mdr）药物的方法，可持续释放方法一种或多种电荷分子和稳定剂胶束利用

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摘要

The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer, such as a polyethylene glycol (PEG) chain, which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of an encapsulated agent in vivo, protecting an encapsulated agent against degradation, and enhancing the water solubility of a drug or other agent.

机译：本发明包括胶束组件，具有胶束组件的组合物以及制备胶束组件的方法及其组合物。本发明还包括与聚合物如聚乙二醇（PEG）链缀合的谷醇溶蛋白蛋白，该缀合物可用于制备胶束组装体。本发明进一步包括使用本发明的缀合物包封分子的方法。胶束组件可用于多种应用，例如治疗癌症，靶向肿瘤，降低体内药物的毒性，提高体内包封剂的功效，保护被包封剂免于降解以及增强水质。药物或其他试剂的溶解度。

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公开/公告号BR112013021732A2

专利类型
公开/公告日2016-11-01

原文格式PDF
申请/专利权人 SOUTH DAKOTA STATE UNIVERSITY;
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申请/专利号BR20131121732
发明设计人 OMATHANU P. PERUMAL;RANJITH KUMAR AVERINENI;SATHEESH PODARALLA;
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申请日2012-02-24
分类号A61K9/127;
国家 BR
入库时间 2022-08-21 14:27:11

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