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mucosal vaccine producing an antigen-specific mucosal ligand and blood igg and method for producing a mucosal vaccine producing an antigen-specific mucosal ligand and a blood igg

机译：产生抗原特异性粘膜配体和血液igg的粘膜疫苗以及产生抗原特异性粘膜配体和血液igg的粘膜疫苗的方法

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摘要

A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxyvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.

机译：一种粘膜疫苗，其产生能够发挥有效的免疫诱导和预防感染作用的水平的抗原特异性粘膜IgA和血液IgG，包括：（a）由合成肽和脂质组成的AD载体，其中该合成肽由氨基酸序列KnLm（其中n为4至8，m为11至20）组成;（b）羧乙烯基聚合物;和，（c）抗原蛋白，当其自身使用时，其量不能产生足够的粘膜IgA和血液IgG，以发挥有效的免疫诱导和预防感染的作用。本发明的粘膜疫苗具有比现有技术的粘膜疫苗更有效的抗体产生能力，其结果是即使使用极少量的抗原也可以发挥优异的效果。

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公开/公告号BR112012022059A2

专利类型
公开/公告日2016-11-01

原文格式PDF
申请/专利权人 THE UNIVERSITY OF TOKUSHIMA;
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申请/专利号BR20121122059
发明设计人 DAI MIZUNO;HIROSHI KIDO;
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申请日2011-03-01
分类号A61K9/127;A61K39;A61K39/02;A61K39/12;A61K39/35;A61K39/39;A61K47/32;A61P31;A61P31/16;
国家 BR
入库时间 2022-08-21 14:27:22

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